Are there any articles you are aware of that compare the different vitrification solutions and additives between cryonics providers, or is this proprietary information? I’m not sure where to look. I’m curious about additives in addition to molecules strictly pertinent to reducing ice formation. Thanks.
I suppose I’ve been pondering the scenario of a standby team with a cryonics patient shortly after the heartbeat ceases and they are declared dead. We initiate cpr to promote blood flow as perfusion begins. Might there be a risk of that triggering the heart to restart or the experience of consciousness? Should the cryoprotectant solution include additives that would take that into consideration?
I also wonder about the addition of oxygen carrying molecules to reduce anoxic damage. And metal containing molecules that could facilitate rewarming later.
Are we at a plateau with cryoprotectant solutions?
Before cryoprotection is even begun, the patient will have been medicated. The first medication given is to prevent consciousness (and to slow metabolism). That was a narcotic in the old days and how it's propofol.
Thanks kindly and that makes sense. Likely blood thinners as well?
Propofol likely wouldn’t preclude restarting the heart??
Are there universal standards on this by cryonics organizations (he asks knowing the answer)?
Seems to me it would be interesting to know how EEG activity changes as perfusion and medication proceed in the ideal situation of the standby team being present at the time death is called.
Anticoagulants, membrane stabilizers, antacids, vasopressors, antibiotics. Aschwin can tell you the current preferred protocol. I think the medication protocol is fairly similar between the major orgs but don't quote me on that.
Are there any articles you are aware of that compare the different vitrification solutions and additives between cryonics providers, or is this proprietary information? I’m not sure where to look. I’m curious about additives in addition to molecules strictly pertinent to reducing ice formation. Thanks.
I have written the following:
https://www.biostasis.com/vitrification-agents-in-cryonics-m22/
https://www.biostasis.com/vitrification-agents-in-cryonics-vm-1/
I will write some kind of update soon because the composition of VM-1 will be changing.
As always, thanks kindly.
I suppose I’ve been pondering the scenario of a standby team with a cryonics patient shortly after the heartbeat ceases and they are declared dead. We initiate cpr to promote blood flow as perfusion begins. Might there be a risk of that triggering the heart to restart or the experience of consciousness? Should the cryoprotectant solution include additives that would take that into consideration?
I also wonder about the addition of oxygen carrying molecules to reduce anoxic damage. And metal containing molecules that could facilitate rewarming later.
Are we at a plateau with cryoprotectant solutions?
Before cryoprotection is even begun, the patient will have been medicated. The first medication given is to prevent consciousness (and to slow metabolism). That was a narcotic in the old days and how it's propofol.
Thanks kindly and that makes sense. Likely blood thinners as well?
Propofol likely wouldn’t preclude restarting the heart??
Are there universal standards on this by cryonics organizations (he asks knowing the answer)?
Seems to me it would be interesting to know how EEG activity changes as perfusion and medication proceed in the ideal situation of the standby team being present at the time death is called.
The amount of sodium citrate in most cryonics protocols will instantaneously stop the heart given its calcium-chelating properties.
Thanks to both you and Max. Sorry, I know this is well discussed elsewhere.
I find fascinating, not so much for me the vitrification aspect as much as the additional drugs, “small volume medications” Aschwin discussed most of this already in https://www.researchgate.net/profile/Aschwin-De-Wolf/publication/344435043_Human_Cryopreservation_Procedures_Book/links/5f7e17f992851c14bcb66e06/Human-Cryopreservation-Procedures-Book.pdf
How these might vary from one organization to another and the clinical justification would be a great read.
Anticoagulants, membrane stabilizers, antacids, vasopressors, antibiotics. Aschwin can tell you the current preferred protocol. I think the medication protocol is fairly similar between the major orgs but don't quote me on that.